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KMID : 1123920130270010063
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Korean Journal of Oriental Physiology and Pathology
2013 Volume.27 No. 1 p.63 ~ p.77
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Anticancer and Related Immunomodulatory and Anticachexic Effects of Insamyangyoung-tang Extracts on Non Small Cell Lung Carcinoma, NCI-H520, Xenograft Mice
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Song Kwang-Kyu
Park Mee-Yeon
Choi Hae-Yun
Kim Jong-Dae
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Abstract
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The object of this study was to observe anticancer and related immunomodulatory and anticachexic effects of Insamyangyoung-tang aqueous extracts (ISYYTe) on non?small cell lung carcinoma (squamous epithelial carcinoma), NCI-H520, xenograft Balb/c nu-nu nude mice. Changes on the tumor volume and weights, lymphatic organ(spleen and popliteal lymph node), serum interferon (IFN)-γ levels, splenocytes and peritoneal macrophage activities (NK cell activity), splenic tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-10 contents, splenic T-lymphocyte subsets (CD3+, CD4+ and CD8+) and TNF-α+ cells were observed with tumor mass and lymphatic organ histopathology to detect anticancer and immunomodulatory effects. In addition, changes on the body weights, epididymal fat weights and serum IL-6 levels were also detected with the thicknesses of deposited cervical brown adipose tissue and their mean diameters to monitor the tumor?related anticachexic effects. The results obtained in this study suggest that over 50 ㎎/㎏ of ISYYTe showed favorable anticancer effects on the NCI-H520 cell xenograft with immunomodulatory and anticachexic effects. However, detail mechanism studies should be conducted in future with the screening of the biological active compounds in this herb.
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KEYWORD
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insamyangyoung-tang(人蔘養榮湯), anticancer, immunomodulatory, cachexia, Non-small Cell Lung Carcinoma, NCI-H520
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